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Clinical Trials

Below are some research studies that are currently active across St. David’s HealthCare. Please continue to check back as we additional trials are added to this list.

For more information about these trials, please visit ClinicalTrials.gov

ProtocolContact PersonContact PhoneStudy StatusResearch AreaStudy Number

CONVERGE – Convergence of Epicardial and Endocardial RF Ablation for the Treatment of Symptomatic Persistent AF (Protocol Version: VAL-1200(D))

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Mary Fraser512-740-0631OpenCardiovascular; Atrial Fibrillation15-08-01

Randomized, Double-Blind, Placebo-Controlled Phase I/II Study of the Safety and Efficacy of Intracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patients with a Myocardial Infarction and Ischemic Left Ventricular Dysfunction (ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration, ALLSTAR)

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Mary Fraser512-740-0631OpenCardiovascular; Stem Cells13-12-02

aMAZE TRIAL Left Atrial Appendage Ligation with the LARIAT® Suture Delivery System as Adjunctive Therapy to Pulmonary Vein Isolation (PVI) for Persistent or Longstanding Persistent Atrial Fibrillation

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Mary Fraser512-740-0631OpenCardiovascular; Atrial Fibrillation15-08-01

The Endologix LEOPARD Study: A Multicenter, Prospective, Randomized, Post-Market, Real-World Study to Assess Outcomes of Patients Treated with the AFX® System Compared to other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Abdominal Aortic Aneurysm15-09-01

“EVOLVE Short DAPT Study (S2073)
A prospective, multicenter, single-arm study designed to assess the safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with a SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System (SYNERGY Stent System)”

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Mary Fraser512-740-0631OpenCardiovascular; Coronary Artery Disease16-02-02

MULTIPOINT PACING POST MARKET STUDY (MPP PMS)

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Mary Fraser512-740-0631OpenCardiovascular; Heart Failure16-08-01

The Austin Brain Tumor Repository

Max Shpak512-544-8077OpenOncology; Tissue bank10-05-03

A Prospective, Multicenter, Single Blind, Randomized, Controlled Trial Comparing the Lutonix Drug Coated Balloon vs. Standard Balloon Angioplasty for Treatment of Below-the-Knee (BTK) Arteries (Lutonix BTK Trial) Protocol # CL0005-01

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Mary Fraser512-740-0631OpenCardiovascular; Peripheral Vascular Disease13-06-02

Study Plan for Evaluation of EPIQ Ultrasound System

Missi Johnson512-407-7497OpenCardiovascular; Echocardiography15-12-04

Patient Outcomes with Periarticular Liposomal Bupivacaine Injection vs Adductor Canal Block after Primary Total Knee Arthroplasty

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Andrea Torres972-849-1198OpenOrthopedics; Pain Management16-04-02

Medtronic Product Surveillance Registry

Deb Cardinal512-458-9410OpenCardiovascular10-03-02

“Immediate vs. Deferred Cardioversion Strategy for Early Recurrence of
Atrial Fibrillation after Ablation (ERAF)”

Deb Cardinal512-458-9410ClosedCardiovascular; Atrial Fibrillation11-12-03

Safety of Oral Anticoagulation Therapy withdrawal after successful Cardiac Ablation in Patients with Atrial Fibrillation and Associated High Risk Factors for Embolic Events (OAT Pilot Study)

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Deb Cardinal512-458-9410ClosedCardiovascular; Paroxysmal Atrial Fibrillation12-06-03

Arrhythmogenic Substrate Evaluation and Ablation in Brugada Syndrome

Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation12-07-03

Impact of the Pulmonary Vein Isolation on Exercise Capacity in Patients with Chronic Atrial Fibrillation

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Deb Cardinal512-458-9410OpenCardiovascular; Chronic Atrial Fibrillation08-11-09

Prophylactic Cervicothoracic Sympathectomy for Prevention of Ventricular Tachycardia (PREVENT VT Trial)

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Deb Cardinal512-458-9410OpenCardiovascular; Ventricular Tachycardia13-04-03

Mild cognitive impairment (MCI) in patients with atrial fibrillation (AF), trajectories of the progression of MCI and factors associated with the progression – COGNITION

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation13-05-01

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation13-08-02

Short, Medium and Long Term Survivorship of Attune Primary Total Knee Prosthesis DePuy Orthopaedics

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Jake Rabin512-583-0217OpenOrthopedics; Knee Replacement14-01-05

Impact of life-Style modification On abLATion outcomE in atrial fibrillation (ISOLATE) – Lifestyle and AF

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation14-06-04

Prospective Review of the Safety and Effectiveness of the THERMOCOOL SMARTTOUCH® SF Catheter Evaluated for Treating Symptomatic PersistenT AF (PRECEPT)

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation14-07-02

Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in AF-DECAF II

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation14-09-01

Medtronic PERIcardial SurGical AOrtic Valve ReplacemeNt Pivotal Trial (PERIGON)

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Aortic Stenosis14-12-02

Multicenter, Double-Blind, Placebo-Controlled Study of Vonapanitase (PRT-201) Administered Immediately after Radiocephalic Arteriovenous Fistula Creation in Patients with Chronic Kidney Disease

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Chronic Kidney Disease15-07-02

REnal SympathetiC denervation to sUpprEss Tachyarrhythmias in ICD Recipients (RESCUE)

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Deb Cardinal512-458-9410ClosedCardiovascular; Ventricular Tachycardia15-08-02

Bipolar Catheter Ablation for the Treatment of Refractory Scar-Related Ventricular Arrhythmia

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Deb Cardinal512-458-9410OpenCardiovascular15-08-03

AWARE: Impact of Anxiety on Cardiac Substrate Modification in Women wth Atrial Fibrillation Underging Catheter Ablation

Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation15-08-04

“REGISTRY of TRANSCAROTID ARTERY REVASCULARIZATION in PATIENTS with SIGNIFICANT CAROTID ARTERY DISEASE
The ROADSTER 2 Registry”

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Carotid Artery Disease15-10-02

Management of Acute Stroke Patients on Treatment with new Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry

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Krishna Saini512-476-7111OpenNeuroscience; Stroke15-10-03

A prospective, multi-center, post market randomized controlled trial comparing VT ablation outcomes using remote MAGNETIC Navigation guided substrate mapping and ablation versus manual approach in a low LVEF population – MAGNETIC VT

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation15-12-02

Assessment of the utility of the Siemens P6 volume ICE catheter
in electrophysiology and structural heart disease procedures

Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation16-02-01

The BARD® VENOVO ™ Venous Stent Study – A Prospective, Non-Randomized, Multi-Center, Single-Arm Study of the Treatment of Iliofemoral Occlusive Disease – an Assessment for Effectiveness and Safety (VERNACULAR) Protocol BPV-14-007

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Peripheral Vascular Disease16-04-04

AdaptResponse Study

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Deb Cardinal512-458-9410OpenCardiovascular; Heart Failure14-07-01

CardioMEMS HF System Post Approval Study

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Mary Fraser512-740-0631OpenCardiovascular; Heart Failure14-11-05

Comparing Induced and evoked Neuro-hemodynamic coupling by laser speckle contrast imaging in the epileptic Human Brain

Krishna Saini512-476-7111OpenNeuroscience; Epilepsy15-04-02

A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients who have Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement (PARTNER 3)

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Mary Fraser512-740-0631OpenCardiovascular; TAVR16-02-04

DOBUTAMINE VERSUS ISOPROTERENOL FOR INDUCIBILITY OF
ATRIAL ARRHYTHMIAS IN ATRIAL FIBRILLATION ABLATION

Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation16-05-01

Portico Re-Sheathable Transcatheter Aortic Valve System

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Mary Fraser512-740-0631OpenCardiovascular; TAVR14-01-04

Prospective Randomized Evaluation of the WATCHMAN LAA Closure Device in Patients with Atrial Fibrillation Versus Long Term Warfarin Therapy – PREVAIL

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation, Stroke10-12-01

Ranolazine ICD Trial (RAID)

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Deb Cardinal512-458-9410ClosedCardiovascular; Ischemic Cardiomyopathy11-04-01

LEVANT 2 The Moxy Drug Coated Balloon Assessment of the Safety and Clinical Performance

Mary Fraser512-740-0631OpenCardiovascular; Peripheral Vascular Disease11-06-01

Intraoperative Optical Imaging of Cerebral Blood Flow

Krishna Saini512-476-7111OpenNeuroscience; Brain imaging11-11-01

Accent MRI Pacemaker and Tendril MRI Lead IDE Study

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Deb Cardinal512-458-9410ClosedCardiovascular; Pacemaker12-05-01

Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation – ZERO AF

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation12-10-01

INGEVITY Active Fixation and Passive Fixation Pace/Sense Lead Study

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Mary Fraser512-740-0631OpenCardovascular; Pacemaker12-12-01

A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the SYNERGY Everolimus-Eluting Stent Platinum Chromium Coronary Stent System (SYNERGY Stent System) for the Treatment of Atheroschlerotic Lesion(s) (EVOLVE II)

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Mary Fraser512-740-0631OpenCardiovascular; Coronary Artery Disease12-08-02

Evaluation of the Safety and Efficacy of the OPTIMIZER II System with Active Fixation Leads in Subjects with Heart Failure Resulting from Systolic Dysfunction – F/X-HF-5

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Deb Cardinal512-458-9410OpenCardiovascular; Heart Failure04-05-03

Continuum Metal Bearing System in Total Hip Arthroplasty, a multi-center, prospective, non-controlled post market surveillance study Zimmer, Inc.

Jake Rabin512-583-0217OpenOrthopedics; Hip Replacement11-08-03

Evaluation of XIENCE PRIME or XIENCE V versus Coronary Artery Bypass Graft Surgery for Effectiveness of Left Main Revasculartization – EXCEL

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Mary Fraser512 740 0631OpenCardiovascular; Peripheral Vascular Disease11-09-03

Prospective Multicenter Open Label Study Examining the Mid- and Long-term Safety and Efficacy of the 3DKnee System with Vitamin E UHMWPE Tibial Inserts (3DKnee with e-plus Insert)

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Jake Rabin512-583-0217OpenOrthopedics; Knee Replacement12-09-03

Pulmonary Vein Reconnection after Pulmonary Vein Antrum Isolation at Different Power Settings Using Adenosine Provocation – ZODIAC

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Deb Cardinal512-458-9410OpenCardiovascular; Paroxysmal12-11-03

QuickFlex 1258T – Left Heart Pacing Lead Post Approval Study

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Deb Cardinal512-458-9410OpenCardiovascular; Heart Failure10-11-04

Pivotal Clinical Study of the CardioFocus Endoscopic Ablation System – Adaptive Contact (EAS-AC) or HEARTLIGHT for the Treatment of Symptomatic Atrial Fibrillation

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation11-11-04

Renal Denervation in Patients with Uncontrolled Hypertension SYMPLICITY HTN-3

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Mary Fraser512-740-0631ClosedRenal; Hypertension11-11-05

Continued Access to PREVAIL (CAP2)

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Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation12-09-05

The Safety and effectiveness of the SAPIEN XT Transcatheter Heart Valve with NovaFlex and Ascendra associated delivery systems in Intermediate and High Risk for Aortic Valve Surgery and Patients Who Cannot Undergo Surgery – PARTNER II

Mary Fraser512-740-0631OpenCardiovascular; Heart Valve12-12-05

Cross-Sectional, Multi-Center Evaluation of 8 Year Metal Ion Trends for a Pinnacle MoM System Used in Primary Total Hip Arthroplasty

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Jake Rabin512-583-0217OpenOrthopedics; Hip Replacement13-02-01

ImageReady MR Conditional Pacing System SAMURAI Clinical Study

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Deb Cardinal512-458-9410OpenCardiovascular; Pacemaker13-03-01

Post Market Clinical Follow-Up Study of the Zimmer Vivacit-E Highly Crosslinked Polyethylene Liner used with the Continuum Acetabular Shell

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Jake Rabin512-583-0217OpenOrthopedics; Hip Replacement13-08-01

Evaluation of ACUITY X4 Quadripolar Coronary Venous Leads and Conditional Approved RELIANCE 4-FRONT Defibrillation Leads – NAVIGATE X4 Boston Scientific

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Deb Cardinal512-458-9410OpenCardiovascular; Pacemaker14-04-02

Evaluation of ACUITY X4 Quadripolar Coronary Venous Leads and Conditional Approved RELIANCE 4-FRONT Defibrillation Leads – NAVIGATE X4 Boston Scientific

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Mary Fraser512-458-9410OpenCardiovascular; Pacemaker14-05-01

Procurement of Human Biospecimens for the Discovery and Validation of Biomarkers for the Prediction, Diagnosis and Management of Disease

Rick CurtisOpenPathology; Tissue bank14-07-03

Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research (PROSPER)

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Krishna Saini512-476-7111OpenNeuroscience; Stroke14-11-01

TactiCath Contact Force Ablation Center Study for Atrial Fibrillation Post Approval Study

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Deb Cardinal512-458-9410OpenCardiovascular; Paroxysmal14-11-02

LIBERTY 360 degrees: Prospective, Observational, Multi-Center Clinical Study to Evaluate Acute and Long Term Clinical and Economic Outcomes of Endovascular Device Intervention in Patients with Distal Outflow Peripheral Arterial Disease (PAD)

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Bonnie Punske, PhD512-651-8406OpenCardiovascular15-01-01

SNP-based microdeletion and aneuploidy registry (SMART)

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Todd Hale, PhD512-821-2540OpenWomen's Health; Genetic testing15-04-01

Endurant Evo US Clinical Trial

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Bonnie Punske, PhD512-651-8406OpenCardiovascular; Abdominal Aneurysm15-04-03

MIMICS-2: The Evaluation of Safety and Efficacy of the BioMimcs 3D Nitinol Stent System in the Femoropopliteal Arteries of Patients with Symptomatic Peripheral Artery Disease

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Mary Fraser512-740-0631OpenCardiovascular; Peripheral Arterial Disease15-06-02

Anthropometric Data Collection of the Bariatric Population Hill-Rom

John Archibeque, MSN512-901-2077ClosedSurgery; Bariatric15-07-03

ILUMIEN III: OPTIMIZER PCI: Optical Coherence Tomography (OCT) Compared to Intravascular Ultrasound (IVUS) and Angiography to Guide Coronary Stent Implantation: a Multicenter Randomized Trial in PCI

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Mary Fraser512-740-0631OpenCardiovascular; Coronary Artery Disease15-10-01

RAINBOW study; a randomized, controlled study evaluating the efficacy and safety of ranibizumab comoared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity

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Margaret Rodriguez512-451-0103OpenOpthalmic; Retinopathy of Prematurity16-04-01

Early Results of 900 Consecutive, Anterior Approach Total Hip Arthroplasties

Andrea Torres972-849-1198OpenOrthopedics; Hip Replacement16-04-03

Myocardial Protection in Adult Cardiac Surgery Utilizing del Nido Cardioplegia – A Retrospective Review (MYPRO RETRO)

Bonnie Punske, PhD512-651-8406OpenCardiovascular; Heart Surgery16-06-01

The association between history of prior hormonal birth control use and endometrioma formation

Shahryar Kavoussi, MD512-444-1414OpenWomen's Health; Endometriosis16-09-01

Historical standard of care versus liposomal bupivacaine in video-assisted thoracoscopic surgery (VATS): a retrospective single-centered cohort study

Nicolas Forcade, PharmD512-447-2211OpenCardiovascular; Thoracic surgery16-09-03

Real World Experience on Premature Battery Depletion of St. Jude Medical Implantable Cardiac Defibrillators

Deb Cardinal512-458-9410ClosedCardiovascular; Implantable cardioverter-defibrillator16-11-01

Proximal Interphalangeal (PIP) Implant

Katie Williams512-551-0375OpenOrthopedics; Figner implant98-11-05H

The Wingspan Stent System and Gateway PTA Balloon Catheter, a Humanitarian Use Device

Skylar Morgan512-926-3876OpenNeurosurgery; Stroke06-01-03H

A Prospective, Single-Arm, Multicenter Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Aortic Bioprosthetic Valve

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Mary Fraser512-421-3841OpenCardiovascular; TAVR17-02-02

Genetics of Heritable Arrythmyia (Heritable Arrhythmia Genetics: HERITAGE)

Deb Cardinal512-458-9410OpenCardiovascular; Atrial Fibrillation17-02-01

Catheter Ablation of Arrhythmias to Improve CRT Response: The ABLATE-CRT Study

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Deb Cardinal512-458-9410OpenCardiovascular; Arrhythmia, Cardiac17-03-01

EMpagliflozin evaluation By measuRing ImpAct on HemodynamiCs in Patients with DiabEtes and Heart Failure (EMBRACE-HF)

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Mary Fraser512-421-3841OpenCardiovascular; Heart Failure17-03-04

Factors impacting couples’ decision making between vasectomy reversal versus sperm retrieval/IVF/ICSI when counseled by Reproductive Urologist and Reproductive Endocrinologist

Parviz K. Kavoussi, MD512-444-1414OpenReproductive Medicine17-03-05X

“The Wingspan Stent System/Gateway PTA Balloon Catheter” HDE

Karen Kim512-494-6024OpenNeurosurgery; Intracranial Neurovascular Stent10-11-01H

Pharmaco-surveillance of oral anticoagulant therapies (OAT) and outcomes

Krishna Saini512-476-7111OpenNeuroscience; Stroke17-03-02

Neuroform Microdelivery Stent System, HDE# H020002

Karen Kim512-494-6024OpenNeuroscience; Neurovascular05-02-02

Codman Enterprise Vascular Reconstruction Device and Delivery System

Krishna Saini512-476-7111OpenNeuroscience; Neurovascular11-12-02H

Neuroform Microdelivery Stent System (HUD, HDE # H020002)

Krishna Saini512-476-7111OpenNeuroscience; Neurovascular11-12-05H

GraftMaster RX

Mary Fraser512-421-3841OpenCardiovascular; Coronary stent graft system02-11-05H

Graftmaster RX

Jayne KingOpenCardiovascular; Coronary stent graft system02-12-02H

Randomized Control Trial: Physical Exam Indicated Cerlage in Twin Gestations (TWIN-PEIC)

Todd Hale, PhD512-821-2540OpenMaternal Fetal Medicine17-03-06W

Safety and Efficacy of Periprocedural Apixaban Use for Reduction of th eRisk of Cerebrovascular Evets in Patients Undergoing Ventricular Tachycardia Radiofrequency Catheter Ablation (STROKE-VT)

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Deb Cardinal512-458-9410OpenCardiovascular; Ventricular Tachycardia17-04-01

Factors associated with subchorionic hematoma formation in pregnancies achieved via assisted reproductive technologies

Shahyar Kavoussi, MD512-444-1414OpenReproductive Medicine17-04-02X

The impact of Promescent on human sperm

Parviz Kavoussi, MD512-444-1414OpenReproductive Medicine17-04-03X

Validation of targeted microsurgical spermatic cord denervation: comparison of outcomes to traditional complete microsurgical spermatic cord denervation

Parviz K. Kavoussi, MD512-444-1414OpenReproductive Medicine17-04-04X

3-Dimensional Echocardiogram Mitral Valve Study

Fred NugenOpenCardiovascular; Heart Valve17-04-05X

A multi-center, prospective, randomized study comparing surgical and economic parameters of Total Knee Replacement performed with single-use Efficiency instruments with patient-specific technique (MyKnee®) versus traditional metal instruments with conventional surgical technique

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Tyler Goldberg, MDOpenOrthopedics; Osteoarthritis17-05-01W

CarboClear Pedicle Screw System IDE Study

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Carl Lauryssen, MDOpenNeuroscience; Spine17-05-02W

TREAT: Treatment of ppROM with Erythromycin vs. Azithromycin Trial

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Richard Todd Hale, PhD512-493-6927OpenCell; Preterm Premature Rupture of Membranes (PPROM)17-06-01

Medtronic Attain Stability Quad Study

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Deb CardinalOpenCardiovascular; Heart Failure17-06-02W

Impella Right Ventricular Assist Device (HDE H140001)

Mary Fraser512-421-3841OpenCardiovascular; Pacemaker17-07-01H

Patient Outcomes with Early vs Delayed Ambulation Following Primary Total Hip Arthroplasty “Early Ambulation Study”

Andrea Torres512-439-1117Open17-07-02

BMT 25 – TV44688-ONC-30054: A Single-Arm Study of the Effect of a 5-day Regimen of Tbo-Filgrastim 10 ìg/kg of Body Weight Administered Subcutaneously on Peripheral Stem Cell Mobilization in Healthy Donors

Brittany White615-524-4149Open17-07-03W