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Clinical Trials

Below are some research studies that are currently active across St. David’s HealthCare. Please continue to check back as we additional trials are added to this list.

For more information about these trials, please visit ClinicalTrials.gov

Link to Specific Study (on clinicaltrials.gov) Protocol Contact Person Contact Phone Study Status (Open/Closed IRB) Service Line Research Area
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CONVERGE – Convergence of Epicardial and Endocardial RF Ablation for the Treatment of Symptomatic Persistent AF (Protocol Version: VAL-1200(D))

Mary Fraser 512-740-0631 open Cardiovascular Atrial Fibrillation
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Randomized, Double-Blind, Placebo-Controlled Phase I/II Study of the Safety and Efficacy of Intracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patients with a Myocardial Infarction and Ischemic Left Ventricular Dysfunction (ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration, ALLSTAR)

Mary Fraser 512-740-0631 open Cardiovascular Stem Cells
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aMAZE TRIAL Left Atrial Appendage Ligation with the LARIAT® Suture Delivery System as Adjunctive Therapy to Pulmonary Vein Isolation (PVI) for Persistent or Longstanding Persistent Atrial Fibrillation

Mary Fraser 512-740-0631 open Cardiovascular Atrial Fibrillation
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The Endologix LEOPARD Study: A Multicenter, Prospective, Randomized, Post-Market, Real-World Study to Assess Outcomes of Patients Treated with the AFX® System Compared to other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Abdominal Aortic Aneurysm
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“EVOLVE Short DAPT Study (S2073)
A prospective, multicenter, single-arm study designed to assess the safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with a SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System (SYNERGY Stent System)

Mary Fraser 512-740-0631 open Cardiovascular Coronary Artery Disease
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MULTIPOINT PACING POST MARKET STUDY (MPP PMS)

Mary Fraser 512-740-0631 open Cardiovascular Heart Failure

The Austin Brain Tumor Repository

Max Shpak 512-544-8077 open Oncology Tissue bank
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A Prospective, Multicenter, Single Blind, Randomized, Controlled Trial Comparing the Lutonix Drug Coated Balloon vs. Standard Balloon Angioplasty for Treatment of Below-the-Knee (BTK) Arteries (Lutonix BTK Trial) Protocol # CL0005-01

Mary Fraser 512-740-0631 open Cardiovascular Peripheral Vascular Disease

Study Plan for Evaluation of EPIQ Ultrasound System

Missi Johnson 512-407-7497 open Cardiovascular Echocardiography
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Patient Outcomes with Periarticular Liposomal Bupivacaine Injection vs Adductor Canal Block after Primary Total Knee Arthroplasty

Andrea Torres 972-849-1198 open Orthopedic Pain Management

Medtronic Product Surveillance Registry

Deb Cardinal 512-458-9410 open Cardiovascular

“Immediate vs. Deferred Cardioversion Strategy for Early Recurrence of
Atrial Fibrillation after Ablation (ERAF)”

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Safety of Oral Anticoagulation Therapy withdrawal after successful Cardiac Ablation in Patients with Atrial Fibrillation and Associated High Risk Factors for Embolic Events (OAT Pilot Study)

Deb Cardinal 512-458-9410 open Cardiovascular Paroxysmal Atrial Fibrillation

Arrhythmogenic Substrate Evaluation and Ablation in Brugada Syndrome

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Impact of the Pulmonary Vein Isolation on Exercise Capacity in Patients with Chronic Atrial Fibrillation

Deb Cardinal 512-458-9410 open Cardiovascular Chronic Atrial Fibrillation
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Prophylactic Cervicothoracic Sympathectomy for Prevention of Ventricular Tachycardia (PREVENT VT Trial)

Deb Cardinal 512-458-9410 open Cardiovascular Ventricular Tachycardia
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Mild cognitive impairment (MCI) in patients with atrial fibrillation (AF), trajectories of the progression of MCI and factors associated with the progression – COGNITION

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Short, Medium and Long Term Survivorship of Attune Primary Total Knee Prosthesis DePuy Orthopaedics

Jake Rabin 512-583-0217 open Orthopedic Knee Replacement
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Impact of life-Style modification On abLATion outcomE in atrial fibrillation (ISOLATE) – Lifestyle and AF

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Prospective Review of the Safety and Effectiveness of the THERMOCOOL SMARTTOUCH® SF Catheter Evaluated for Treating Symptomatic PersistenT AF (PRECEPT)

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Determining the association of chromosomal variants with non-PV triggers and ablation-outcome in AF-DECAF II

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Medtronic PERIcardial SurGical AOrtic Valve ReplacemeNt Pivotal Trial (PERIGON)

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Aortic Stenosis
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Multicenter, Double-Blind, Placebo-Controlled Study of Vonapanitase (PRT-201) Administered Immediately after Radiocephalic Arteriovenous Fistula Creation in Patients with Chronic Kidney Disease

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Chronic Kidney Disease
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REnal SympathetiC denervation to sUpprEss Tachyarrhythmias in ICD Recipients (RESCUE)

Deb Cardinal 512-458-9410 open Cardiovascular Ventricular Tachycardia
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Bipolar Catheter Ablation for the Treatment of Refractory Scar-Related Ventricular Arrhythmia

Deb Cardinal 512-458-9410 open Cardiovascular Cardiovascular

AWARE: Impact of Anxiety on Cardiac Substrate Modification in Women wth Atrial Fibrillation Underging Catheter Ablation

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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“REGISTRY of TRANSCAROTID ARTERY REVASCULARIZATION in PATIENTS with SIGNIFICANT CAROTID ARTERY DISEASE
The ROADSTER 2 Registry”

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Carotid Artery Disease
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Management of Acute Stroke Patients on Treatment with new Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry

Sergio Michel 512-633-7364 open Neuroscience Stroke
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A prospective, multi-center, post market randomized controlled trial comparing VT ablation outcomes using remote MAGNETIC Navigation guided substrate mapping and ablation versus manual approach in a low LVEF population – MAGNETIC VT

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation

Assessment of the utility of the Siemens P6 volume ICE catheter
in electrophysiology and structural heart disease procedures

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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The BARD® VENOVO ™ Venous Stent Study – A Prospective, Non-Randomized, Multi-Center, Single-Arm Study of the Treatment of Iliofemoral Occlusive Disease – an Assessment for Effectiveness and Safety (VERNACULAR) Protocol BPV-14-007

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Peripheral Vascular Disease
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AdaptResponse Study

Deb Cardinal 512-458-9410 open Cardiovascular Heart Failure
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CardioMEMS HF System Post Approval Study

Mary Fraser 512-740-0631 open Cardiovascular Heart Failure

Comparing Induced and evoked Neuro-hemodynamic coupling by laser speckle contrast imaging in the epileptic Human Brain

Sergio Michel 512-633-7364 open Neuroscience Epilepsy
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A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients who have Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement (PARTNER 3)

Mary Fraser 512-740-0631 open Cardiovascular TAVR

DOBUTAMINE VERSUS ISOPROTERENOL FOR INDUCIBILITY OF
ATRIAL ARRHYTHMIAS IN ATRIAL FIBRILLATION ABLATION

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Portico Re-Sheathable Transcatheter Aortic Valve System

Mary Fraser 512-740-0631 open Cardiovascular TAVR
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Prospective Randomized Evaluation of the WATCHMAN LAA Closure Device in Patients with Atrial Fibrillation Versus Long Term Warfarin Therapy – PREVAIL

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation, Stroke
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Ranolazine ICD Trial (RAID)

Deb Cardinal 512-458-9410 open Cardiovascular Ischemic Cardiomyopathy

LEVANT 2 The Moxy Drug Coated Balloon Assessment of the Safety and Clinical Performance

Mary Fraser 512-740-0631 open Cardiovascular Peripheral Vascular Disease

Intraoperative Optical Imaging of Cerebral Blood Flow

Sergio Michel 512-633-7364 open Neuroscience Brain imaging
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Accent MRI Pacemaker and Tendril MRI Lead IDE Study

Deb Cardinal 512-458-9410 open Cardiovascular Pacemaker
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Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation – ZERO AF

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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INGEVITY Active Fixation and Passive Fixation Pace/Sense Lead Study

Mary Fraser 512-740-0631 open Cardovascular Pacemaker
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A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the SYNERGY Everolimus-Eluting Stent Platinum Chromium Coronary Stent System (SYNERGY Stent System) for the Treatment of Atheroschlerotic Lesion(s) (EVOLVE II)

Mary Fraser 512-740-0631 open Cardiovascular Coronary Artery Disease
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Evaluation of the Safety and Efficacy of the OPTIMIZER II System with Active Fixation Leads in Subjects with Heart Failure Resulting from Systolic Dysfunction – F/X-HF-5

Deb Cardinal 512-458-9410 open Cardiovascular Heart Failure

Continuum Metal Bearing System in Total Hip Arthroplasty, a multi-center, prospective, non-controlled post market surveillance study Zimmer, Inc.

Jake Rabin 512-583-0217 open Orthopedic Hip Replacement
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Evaluation of XIENCE PRIME or XIENCE V versus Coronary Artery Bypass Graft Surgery for Effectiveness of Left Main Revasculartization – EXCEL

Mary Fraser 512 740 0631 open Cardiovascular Peripheral Vascular Disease
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Prospective Multicenter Open Label Study Examining the Mid- and Long-term Safety and Efficacy of the 3DKnee System with Vitamin E UHMWPE Tibial Inserts (3DKnee with e-plus Insert)

Jake Rabin 512-583-0217 open Orthopedic Knee Replacement
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Pulmonary Vein Reconnection after Pulmonary Vein Antrum Isolation at Different Power Settings Using Adenosine Provocation – ZODIAC

Deb Cardinal 512-458-9410 open Cardiovascular Paroxysmal
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QuickFlex 1258T – Left Heart Pacing Lead Post Approval Study

Deb Cardinal 512-458-9410 open Cardiovascular Heart Failure
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Pivotal Clinical Study of the CardioFocus Endoscopic Ablation System – Adaptive Contact (EAS-AC) or HEARTLIGHT for the Treatment of Symptomatic Atrial Fibrillation

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Renal Denervation in Patients with Uncontrolled Hypertension SYMPLICITY HTN-3

Mary Fraser 512-740-0631 open Renal Hypertension
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Continued Access to PREVAIL (CAP2)

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation

The Safety and effectiveness of the SAPIEN XT Transcatheter Heart Valve with NovaFlex and Ascendra associated delivery systems in Intermediate and High Risk for Aortic Valve Surgery and Patients Who Cannot Undergo Surgery – PARTNER II

Mary Fraser 512-740-0631 open Cardiovascular Heart Valve
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Cross-Sectional, Multi-Center Evaluation of 8 Year Metal Ion Trends for a Pinnacle MoM System Used in Primary Total Hip Arthroplasty

Jake Rabin 512-583-0217 open Orthopedic Hip Replacement
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ImageReady MR Conditional Pacing System SAMURAI Clinical Study

Deb Cardinal 512-458-9410 open Cardiovascular Pacemaker
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Post Market Clinical Follow-Up Study of the Zimmer Vivacit-E Highly Crosslinked Polyethylene Liner used with the Continuum Acetabular Shell

Jake Rabin 512-583-0217 open Orthopedic Hip Replacement
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Evaluation of ACUITY X4 Quadripolar Coronary Venous Leads and Conditional Approved RELIANCE 4-FRONT Defibrillation Leads – NAVIGATE X4 Boston Scientific

Deb Cardinal 512-458-9410 open Cardiovascular Pacemaker
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Evaluation of ACUITY X4 Quadripolar Coronary Venous Leads and Conditional Approved RELIANCE 4-FRONT Defibrillation Leads – NAVIGATE X4 Boston Scientific

Mary Fraser 512-458-9410 open Cardiovascular Pacemaker

Procurement of Human Biospecimens for the Discovery and Validation of Biomarkers for the Prediction, Diagnosis and Management of Disease

Rick Curtis open Pathology Tissue bank
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Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research (PROSPER)

Sergio Michel 512-633-7364 open Neuroscience Stroke
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TactiCath Contact Force Ablation Center Study for Atrial Fibrillation Post Approval Study

Deb Cardinal 512-458-9410 open Cardiovascular Paroxysmal
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LIBERTY 360 degrees: Prospective, Observational, Multi-Center Clinical Study to Evaluate Acute and Long Term Clinical and Economic Outcomes of Endovascular Device Intervention in Patients with Distal Outflow Peripheral Arterial Disease (PAD)

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Cardiovascular
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SNP-based microdeletion and aneuploidy registry (SMART)

Todd Hale, PhD 512-821-2540 open Women's Health Genetic testing
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Endurant Evo US Clinical Trial

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Abdominal Aneurysm
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MIMICS-2: The Evaluation of Safety and Efficacy of the BioMimcs 3D Nitinol Stent System in the Femoropopliteal Arteries of Patients with Symptomatic Peripheral Artery Disease

Mary Fraser 512-740-0631 open Cardiovascular Peripheral Arterial Disease

Anthropometric Data Collection of the Bariatric Population Hill-Rom

John Archibeque, MSN 512-901-2077 open Surgery Bariatric
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ILUMIEN III: OPTIMIZER PCI: Optical Coherence Tomography (OCT) Compared to Intravascular Ultrasound (IVUS) and Angiography to Guide Coronary Stent Implantation: a Multicenter Randomized Trial in PCI

Mary Fraser 512-740-0631 open Cardiovascular Coronary Artery Disease
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RAINBOW study; a randomized, controlled study evaluating the efficacy and safety of ranibizumab comoared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity

Margaret Rodriguez 512-451-0103 open Opthalmic Retinopathy of Prematurity

Early Results of 900 Consecutive, Anterior Approach Total Hip Arthroplasties

Andrea Torres 972-849-1198 open Orthopedic Hip Replacement

Myocardial Protection in Adult Cardiac Surgery Utilizing del Nido Cardioplegia – A Retrospective Review (MYPRO RETRO)

Bonnie Punske, PhD 512-651-8406 open Cardiovascular Heart Surgery

The association between history of prior hormonal birth control use and endometrioma formation

Shahryar Kavoussi, MD 512-444-1414 open Women's Health Endometriosis

Historical standard of care versus liposomal bupivacaine in video-assisted thoracoscopic surgery (VATS): a retrospective single-centered cohort study

Nicolas Forcade, PharmD 512-447-2211 open Cardiovascular Thoracic surgery

Real World Experience on Premature Battery Depletion of St. Jude Medical Implantable Cardiac Defibrillators

Deb Cardinal 512-458-9410 open Cardiovascular Implantable cardioverter-defibrillator

Proximal Interphalangeal (PIP) Implant

Katie Williams 512-551-0375 open Orthopedic Figner implant

The Wingspan Stent System and Gateway PTA Balloon Catheter, a Humanitarian Use Device

Skylar Morgan 512-926-3876 open Neurosurgery Stroke
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A Prospective, Single-Arm, Multicenter Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Aortic Bioprosthetic Valve

Mary Fraser 512-421-3841 open Cardiovascular TAVR

Genetics of Heritable Arrythmyia (Heritable Arrhythmia Genetics: HERITAGE)

Deb Cardinal 512-458-9410 open Cardiovascular Atrial Fibrillation
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Catheter Ablation of Arrhythmias to Improve CRT Response: The ABLATE-CRT Study

Deb Cardinal 512-458-9410 open Cardiovascular Arrhythmia, Cardiac
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EMpagliflozin evaluation By measuRing ImpAct on HemodynamiCs in Patients with DiabEtes and Heart Failure (EMBRACE-HF)

Mary Fraser 512-421-3841 open Cardiovascular Heart Failure

Factors impacting couples’ decision making between vasectomy reversal versus sperm retrieval/IVF/ICSI when counseled by Reproductive Urologist and Reproductive Endocrinologist

Parviz K. Kavoussi, MD 512-444-1414 open Reproductive Medicine

“The Wingspan Stent System/Gateway PTA Balloon Catheter” HDE

Karen Kim 512-494-6024 open Neurosurgery Intracranial Neurovascular Stent

Pharmaco-surveillance of oral anticoagulant therapies (OAT) and outcomes

Sergio Michel 512-544-8070 open Neuroscience Stroke

Neuroform Microdelivery Stent System, HDE# H020002

Karen Kim 512-494-6024 open Neuroscience Neurovascular

Codman Enterprise Vascular Reconstruction Device and Delivery System

Sergio Michel 512-544-8070 open Neuroscience Neurovascular

Neuroform Microdelivery Stent System (HUD, HDE # H020002)

Sergio Michel 512-544-8070 open Neuroscience Neurovascular

GraftMaster RX

Mary Fraser 512-421-3841 open Cardiovascular Coronary stent graft system

Graftmaster RX

Jayne King open Cardiovascular Coronary stent graft system

Randomized Control Trial: Physical Exam Indicated Cerlage in Twin Gestations (TWIN-PEIC)

Todd Hale, PhD 512-821-2540 open
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Safety and Efficacy of Periprocedural Apixaban Use for Reduction of th eRisk of Cerebrovascular Evets in Patients Undergoing Ventricular Tachycardia Radiofrequency Catheter Ablation (STROKE-VT)

Deb Cardinal 512-458-9410 open Cardiovascular Ventricular Tachycardia

Factors associated with subchorionic hematoma formation in pregnancies achieved via assisted reproductive technologies

Shahyar Kavoussi, MD 512-444-1414 open Reproductive Medicine

The impact of Promescent on human sperm

Parviz Kavoussi, MD 512-444-1414 open Reproductive Medicine

Validation of targeted microsurgical spermatic cord denervation: comparison of outcomes to traditional complete microsurgical spermatic cord denervation

Parviz K. Kavoussi, MD 512-444-1414 open Reproductive Medicine

3-Dimensional Echocardiogram Mitral Valve Study

Fred Nugen open Cardiovascular Heart Valve
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A multi-center, prospective, randomized study comparing surgical and economic parameters of Total Knee Replacement performed with single-use Efficiency instruments with patient-specific technique (MyKnee®) versus traditional metal instruments with conventional surgical technique

Tyler Goldberg, MD open Orthopedic Osteoarthritis
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CarboClear Pedicle Screw System IDE Study

Carl Lauryssen, MD open Neuroscience Spine
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TREAT: Treatment of ppROM with Erythromycin vs. Azithromycin Trial

Richard Todd Hale, PhD 512-493-6927 open Cell Preterm Premature Rupture of Membranes (PPROM)
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Medtronic Attain Stability Quad Study

Deb Cardinal open Cardiovascular Heart Failure

Impella Right Ventricular Assist Device (HDE H140001)

Mary Fraser 512-421-3841 open Cardiovascular Pacemaker

Patient Outcomes with Early vs Delayed Ambulation Following Primary Total Hip Arthroplasty “Early Ambulation Study”

Andrea Torres 512-439-1117 open Orthopedic Hip Replacement

BMT 25 – TV44688-ONC-30054: A Single-Arm Study of the Effect of a 5-day Regimen of Tbo-Filgrastim 10 ìg/kg of Body Weight Administered Subcutaneously on Peripheral Stem Cell Mobilization in Healthy Donors

Brittany White 615-524-4149 open Oncology Blood & Marrow Transplant
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“SALUS – The Direct Flow Medical® Transcatheter Aortic Valve
Replacement System Pivotal Trial.
Protocol #IP011”

completed Cardiovascular Aortic Valve Stenosis
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To Demonstrate the Safety and Effectiveness of the SurgWerksTM-CLI Kit and VXPTM System for the Rapid Intra-operative Aspiration, Preparation and Intramuscular Injection of Concentrated Autologous Bone Marrow Cells into the Ischemic Index Limb of Rutherford Category 5 Non-Reconstructable Critical Limb Ischemia Patients (CLIRST III)

completed Orthopedic Critical Limb Ischemia (CLI)

Determining the link between genetic mutations and electrophysiological phenotypes in atrial fibrillation: DELTA-AF

completed Cardiovascular Genetics
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“reMARQable – nMARQ™ Pulmonary Vein Isolation System for the
Treatment of Paroxysmal Atrial “

completed Cardiovascular Atrial Fibrillation
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A Prospective, Randomized Study of the Hansen System for Introducing and Positioning the ThermoCool Catheter in Patients with Atrial Fibrillation

completed Cardiovascular Paroxysmal Atrial Fibrillation
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Ranolazine ICD Trial (RAID)

completed Cardiovascular Atrial Fibrillation
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The Treatment of Iliac and Femoral Atherosclerotic Lesions Using the Self-expanding Astron and Astron Pulsar Stents BIOFLEX-1

completed Cardiovascular Peripheral Artery DiseasePeripheral Vascular Disease

Effects of Deep Brain Stimulation on Striatal Dopamine in Parkinson’s Disease

completed Neuroscience Parkinson's Disease

Comparison of Ablation-Outcome in Paroxysmal Atrial Fibrillation Patients Using Radiofrequency versus Cryo Energy – CRYO

completed Cardiovascular Atrial Fibrillation
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Outcome of different ablation strategies in long-standing persistent atrial fibrillation (OASIS)

completed Cardiovascular Atrial Fibrillation
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Prospective, Single Arm Multiconfiguration Investigation to Assess the Functional Performance of Attune Primary Knee Arthroplasty System

completed Orthopedic Osteoarthritis

Anthropometric Data Collection of the Bariatric Population Hill-Rom

completed Bariatrics Quality improvement
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EFFECTS OF DAPAGLIFLOZIN ON BIOMARKERS, SYMPTOMS AND FUNCTIONAL STATUS IN ATIENTS WITH TYPE 2 DIABETES OR PRE-DIABETES, AND PRESERVED EJECTION FRACTION HEART FAILURE (PRESERVED-HF TRIAL)

completed Cardiovascular Chronic Heart Failure With Preserved Systolic Function